Breakthrough! New 'once-daily' male contraceptive pill found to safe and effective

Contraceptive Pills For Men Will Become A Reality As The Trials Revealed Positive Results

Dr. Page said her group will begin a 3-month study in April to see if any long-term toxicity appears, and then will do a study in couples to determine if DMAU does efficiently work as birth control.

Dimethandrolone undecanoate contains an androgen like testosterone and progestin, according to University of Washington professor and lead study investigator Dr. Stephanie Page. The study was presented yesterday (18th of March 2018) at the ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago, Illinois. From investigations into an ancient African compound traditionally used to poison arrow tips, to a topical gel that is now undergoing human clinical trials, there are an intriguing variety of methods being investigated for male contraception.

When it debuted in 1960, the birth control pill set off a social revolution, and a legal fight, that's still unfolding almost 60 years later.

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This new pill has overcome some previous challenges facing male birth control, like damage to the liver and other parts of the body. Researchers added another fatty acid, undecanoate, to slow clearance, meaning the pill had a much longer and focused effect to prevent pregnancy.

Arthi Thirumalai, M.B.B.S., from the University of Washington Medical Center in Seattle, and colleagues examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of 28 days of daily dosed oral DMAU in healthy men aged 18 to 50 years. DMAU must be taken with food to be effective, said Page. Researchers say longer term studies are now underway to confirm that the pill can block sperm production so a man cannot get his partner pregnant.

"Despite having low levels of circulating testosterone, very few subjects reported symptoms consistent with testosterone deficiency or excess", says Page.

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There was no significant change in mood or sexual function, but a small number of participants experienced decreased libido during the study. But both of these effects were mild, Page said. "Testosterone production is blocked and therefore sperm are not able to finish their last stages of maturation", she said. The highest dose group displayed the most effective results showing "marked suppression" of testosterone levels and specific hormones related to sperm production. "We know that when we give it to 100 people, it seemed ok; let's see what happens when we give it to 10,000 people", Courgi told Live Science.

The tests revealed that the pill does not result in significantly negative side effects, but more research may be needed to further establish it as safe and effective.

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